4PZZ
Second-site screening of K-Ras in the presence of covalently attached first-site ligands
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | K-Ras | polymer | 170 | 19370.9 | 1 | UniProt (P01116) Pfam (PF00071) | Homo sapiens | |
| 2 | B (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | 1H-benzimidazol-2-ylmethanethiol | non-polymer | 164.2 | 1 | Chemie (2XO) | |||
| 5 | E (A) | water | water | 18.0 | 304 | Chemie (HOH) |
Sequence modifications
A: 1 - 169 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Val 12 | Gly 12 | engineered mutation |
| Cys 39 | Ser 39 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19370.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 631.7 | |
| All* | Total formula weight | 20002.6 |
