4PZY
Second-site screening of K-Ras in the presence of covalently attached first-site ligands
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | K-Ras | polymer | 170 | 19329.8 | 2 | UniProt (P01116) Pfam (PF00071) | Homo sapiens | |
| 2 | C, E (A, B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 3 | D, F (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | G, H (B) | 2-chloro-1-(1H-indol-3-yl)ethanone | non-polymer | 193.6 | 2 | Chemie (2XR) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 352 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 169 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Val 12 | Gly 12 | engineered mutation |
| Cys 70 | Gln 70 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38659.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1322.3 | |
| All* | Total formula weight | 39982.0 |
