4PYO
Humanized rat COMT bound to SAH, semi-holo form
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Catechol O-methyltransferase | polymer | 221 | 24694.3 | 2 | UniProt (P22734) Pfam (PF01596) In PDB | Rattus norvegicus (brown rat rat rats) | |
| 2 | A, B | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
| 3 | A | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 4 | B | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A, B: 44 - 264 (UniProt: P22734)
| PDB | External Database | Details |
|---|---|---|
| Ile 134 | Met 134 | engineered mutation |
| Cys 138 | Tyr 138 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49388.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 832.2 | |
| All* | Total formula weight | 50220.9 |
