4PYO
Humanized rat COMT bound to SAH, semi-holo form
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Catechol O-methyltransferase | polymer | 221 | 24694.3 | 2 | UniProt (P22734) Pfam (PF01596) | Rattus norvegicus (brown rat rat rats) | |
| 2 | C, E (A, B) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) PubChem (16760024) PubChem (193) PubChem (25210495) PubChem (13792) PubChem (177678424) PubChem (44361184) PubChem (21125603) PubChem (46936206) PubChem (50989525) PubChem (25203782) PubChem (51380914) PubChem (52224398) PubChem (189149) PubChem (57544532) PubChem (439155) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (52224400) PubChem (5284331) PubChem (6419189) PubChem (118374891) PubChem (118560068) PubChem (71170554) PubChem (13231890) PubChem (164157219) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) | |||
| 3 | D (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) PubChem (813) | |||
| 4 | F (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A, B: 44 - 264 (UniProt: P22734)
| PDB | External Database | Details |
|---|---|---|
| Ile 134 | Met 134 | engineered mutation |
| Cys 138 | Tyr 138 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49388.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 832.2 | |
| All* | Total formula weight | 50220.9 |
