4PXX
Crystal structure of a highly thermal stabilized variant of Human Carbonic Anhydrase II
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Carbonic anhydrase 2 | polymer | 260 | 29277.9 | 1 | UniProt (P00918) Pfam (PF00194) | Homo sapiens (human) | Carbonate dehydratase II, Carbonic anhydrase C, CAC, Carbonic anhydrase II, CA-II |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | CHOLIC ACID | non-polymer | 408.6 | 1 | Chemie (CHD) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | E (A) | water | water | 18.0 | 127 | Chemie (HOH) |
Sequence modifications
A: 1 - 261 (UniProt: P00918)
| PDB | External Database | Details |
|---|---|---|
| Cys 23 | Ala 23 | engineered mutation |
| His 100 | Leu 100 | engineered mutation |
| Cys 203 | Leu 202 | engineered mutation |
| Ser 206 | Cys 205 | engineered mutation |
| Ser 224 | Leu 223 | engineered mutation |
| Pro 240 | Leu 239 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29277.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 498.3 | |
| All* | Total formula weight | 29776.2 |
