4PXS

Human GKRP bound to AMG-0265 (N-[(R)-(2-CHLOROPHENYL){7-[4-(2-HYDROXYPROPAN-2-YL) PYRIDIN-2-YL]-1-BENZOTHIOPHEN-2-YL}METHYL]CYCLOPROPANESULFONAMIDE) and Sorbitol-6-phosphate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Glucokinase regulatory protein	polymer	638	70306.6	2	UniProt (Q14397) Pfam (PF22645) Pfam (PF22198) Pfam (PF20741)	Homo sapiens (human)	GKRP, Glucokinase regulator
2	C, R (A, B)	N-[(R)-(2-chlorophenyl){7-[4-(2-hydroxypropan-2-yl)pyridin-2-yl]-1-benzothiophen-2-yl}methyl]cyclopropanesulfonamide	non-polymer		513.1	2	Chemie (2Y6) PubChem (89905724) PubChem (72548598)
3	D, S (A, B)	D-SORBITOL-6-PHOSPHATE	non-polymer		262.2	2	Chemie (S6P) PubChem (618) PubChem (21968234) PubChem (17754155) PubChem (130418) PubChem (152306) PubChem (440969) PubChem (445703) PubChem (53827506) PubChem (92209470) PubChem (92177220) PubChem (124335010) PubChem (14620017) PubChem (163321747) PubChem (165361689)
4	AA, BA, CA, DA, E... (B, A)	IODIDE ION	non-polymer		126.9	29	Chemie (IOD) PubChem (30165)
5	JA, KA (B)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL) PubChem (753)
6	LA, MA, NA (B)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
7	OA, PA (A, B)	water	water		18.0	84	Chemie (HOH)

Sequence modifications

A, B: 1 - 625 (UniProt: Q14397)

PDB	External Database	Details
Met -11	-	initiating methionine
Ala -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Asp -3	-	expression tag
Glu -2	-	expression tag
Val -1	-	expression tag
Asp 0	-	expression tag
Gly 626	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	140613.2
Non-Polymers*	Number of molecules	38
	Total formula weight	5703.0
All*	Total formula weight	146316.3

*Water molecules are not included.