4PXM
The Estrogen Receptor Alpha Ligand Binding Domain D538G Mutant in Complex with Estradiol and a glucocorticoid receptor-interacting protein 1 NR box II peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Estrogen receptor | polymer | 271 | 30888.3 | 2 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1 |
| 2 | C, D (C, D) | Nuclear receptor coactivator 2 | polymer | 13 | 1579.9 | 2 | UniProt (Q15596) | Homo sapiens | NCoA-2, Class E basic helix-loop-helix protein 75, bHLHe75, Transcriptional intermediary factor 2, hTIF2 |
| 3 | E, F (A, B) | ESTRADIOL | non-polymer | 272.4 | 2 | Chemie (EST) PubChem (16757676) PubChem (1807201) PubChem (450) PubChem (177015577) PubChem (5757) PubChem (5998) PubChem (10596) PubChem (14880) PubChem (43912931) PubChem (44284023) PubChem (68570) PubChem (46781508) PubChem (54403267) PubChem (56624791) PubChem (57041922) PubChem (58650893) PubChem (59084698) PubChem (1807200) PubChem (68014581) PubChem (68209947) PubChem (70220248) PubChem (70864205) PubChem (667480) PubChem (667515) PubChem (721867) PubChem (928284) PubChem (1258565) PubChem (5317221) PubChem (91740223) PubChem (5317222) PubChem (5745505) PubChem (6328313) PubChem (6432565) PubChem (6560352) PubChem (6603846) PubChem (101691329) PubChem (6918968) PubChem (6919041) PubChem (7000012) PubChem (7004689) PubChem (7048584) PubChem (7048670) PubChem (118548795) PubChem (7061189) PubChem (7067800) PubChem (9795489) PubChem (9811784) PubChem (9903595) PubChem (9938293) PubChem (12313788) PubChem (11869602) PubChem (11870431) PubChem (12313787) PubChem (12313791) PubChem (12313794) PubChem (162947701) PubChem (166849971) PubChem (126969992) PubChem (129010410) PubChem (129317336) PubChem (130307439) PubChem (130307440) PubChem (143489158) PubChem (144605119) PubChem (145157829) PubChem (145610824) PubChem (154109755) PubChem (172873304) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 87 | Chemie (HOH) |
Sequence modifications
A, B: 299 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Val 284 | - | expression tag |
| Asp 285 | - | expression tag |
| Leu 286 | - | expression tag |
| Gly 287 | - | expression tag |
| Thr 288 | - | expression tag |
| Glu 289 | - | expression tag |
| Asn 290 | - | expression tag |
| Leu 291 | - | expression tag |
| Tyr 292 | - | expression tag |
| Phe 293 | - | expression tag |
| Gln 294 | - | expression tag |
| Ser 295 | - | expression tag |
| Asn 296 | - | expression tag |
| Ala 297 | - | expression tag |
| Met 298 | - | expression tag |
| Gly 538 | Asp 538 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 64936.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 544.8 | |
| All* | Total formula weight | 65481.0 |
