4PT6
The discobody: an engineered discoidin domain from factor VIII that binds v 3 integrin with antibody-like affinities
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Coagulation factor VIII | polymer | 169 | 19170.8 | 2 | UniProt (P00451) Pfam (PF00754) | Homo sapiens (human) | Antihemophilic factor, AHF, Procoagulant component, Factor VIIIa heavy chain, 200 kDa isoform, Factor VIIIa heavy chain, 92 kDa isoform, Factor VIII B chain, Factor VIIIa light chain |
| 2 | C, D (A, B) | water | water | 18.0 | 38 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 163 (UniProt: P00451)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | expression tag |
| - | Phe 2215 | deletion |
| - | Thr 2216 | deletion |
| - | Asn 2217 | deletion |
| - | Met 2218 | deletion |
| - | Phe 2219 | deletion |
| Cys 28 | - | expression tag |
| Arg 29 | - | expression tag |
| Gly 30 | - | expression tag |
| Asp 31 | - | expression tag |
| Cys 33 | - | expression tag |
| Ala 82 | Leu 2270 | conflict |
| Ala 83 | Leu 2271 | conflict |
| Glu 164 | - | expression tag |
| Asn 165 | - | expression tag |
| Leu 166 | - | expression tag |
| Tyr 167 | - | expression tag |
| Phe 168 | - | expression tag |
| Gln 169 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38341.6 | |
| All* | Total formula weight | 38341.6 |
