4PMS
The structure of TrkA kinase bound to the inhibitor 4-naphthalen-1-yl-1-[(5-phenyl-1,2,4-oxadiazol-3-yl)methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | High affinity nerve growth factor receptor | polymer | 291 | 33232.4 | 1 | UniProt (P04629) Pfam (PF07714) In PDB | Homo sapiens (Human) | Neurotrophic tyrosine kinase receptor type 1,TRK1-transforming tyrosine kinase protein,Tropomyosin-related kinase A,Tyrosine kinase receptor,Tyrosine kinase receptor A,Trk-A,gp140trk,p140-TrkA |
| 2 | A | 4-(naphthalen-1-yl)-1-[(5-phenyl-1,2,4-oxadiazol-3-yl)methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid | non-polymer | 446.5 | 1 | Chemie (31X) | |||
| 3 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | A | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 5 | water | water | 18.0 | 26 | Chemie (HOH) |
Sequence modifications
A: 501 - 787 (UniProt: P04629)
| PDB | External Database | Details |
|---|---|---|
| His 788 | - | expression tag |
| His 789 | - | expression tag |
| His 790 | - | expression tag |
| His 791 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33232.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 659.0 | |
| All* | Total formula weight | 33891.4 |
