4PKY

ARNT/HIF transcription factor/coactivator complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	Aryl hydrocarbon receptor nuclear translocator	polymer	121	14243.1	2	UniProt (P27540) Pfam (PF14598) In PDB	Homo sapiens (Human)	ARNT protein,Class E basic helix-loop-helix protein 2,bHLHe2,Dioxin receptor,nuclear translocator,Hypoxia-inducible factor 1-beta,HIF1-beta
2	B, C, E, F	Transforming acidic coiled-coil-containing protein 3	polymer	50	5814.7	4	UniProt (Q9JJ11) In PDB	Mus musculus (Mouse)	ARNT-interacting protein
3	G	Endothelial PAS domain-containing protein 1	polymer	117	13538.3	1	UniProt (Q99814) Pfam (PF14598) In PDB	Homo sapiens (Human)	EPAS-1,Basic-helix-loop-helix-PAS protein MOP2,Class E basic helix-loop-helix protein 73,bHLHe73,HIF-1-alpha-like factor,HLF,Hypoxia-inducible factor 2-alpha,HIF2-alpha,Member of PAS protein 2,PAS domain-containing protein 2
4	B	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)

Sequence modifications

A, D: 356 - 470 (UniProt: P27540)

PDB	External Database	Details
Gly 350	-	expression tag
Glu 351	-	expression tag
Phe 352	-	expression tag
Lys 353	-	expression tag
Gly 354	-	expression tag
Leu 355	-	expression tag
Arg 362	Glu 348	engineered mutation

B, C, E, F: 585 - 631 (UniProt: Q9JJ11)

PDB	External Database	Details
Gly 582	-	expression tag
Glu 583	-	expression tag
Phe 584	-	expression tag

G: 239 - 350 (UniProt: Q99814)

PDB	External Database	Details
Gly 234	-	expression tag
Glu 235	-	expression tag
Phe 236	-	expression tag
Lys 237	-	expression tag
Gly 238	-	expression tag
Glu 247	Arg 247	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	65283.4
Non-Polymers*	Number of molecules	2
	Total formula weight	192.1
All*	Total formula weight	65475.5

*Water molecules are not included.