4PJ1

Crystal structure of the human mitochondrial chaperonin symmetrical 'football' complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	60 kDa heat shock protein, mitochondrial	polymer	558	59859.5	14	UniProt (P10809) Pfam (PF00118) In PDB	Homo sapiens (Human)	60 kDa chaperonin,Chaperonin 60,CPN60,Heat shock protein 60,Hsp60,HuCHA60,Mitochondrial matrix protein P1,P60 lymphocyte protein
2	O, P, Q, R, S...	10 kDa heat shock protein, mitochondrial	polymer	114	12335.3	14	UniProt (P61604) Pfam (PF00166) In PDB	Homo sapiens (Human)	Hsp10,10 kDa chaperonin,Chaperonin 10,CPN10,Early-pregnancy factor,EPF
3	M, A, N, B, C...	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	14	Chemie (ADP)
4	M, A, N, B, C...	MAGNESIUM ION	non-polymer		24.3	14	Chemie (MG)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L, M, N: 3 - 532 (UniProt: P10809)

PDB	External Database	Details
Met -25	-	expression tag
Gly -24	-	expression tag
Ser -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Gly -14	-	expression tag
Ser -13	-	expression tag
Asp -12	-	expression tag
Tyr -11	-	expression tag
Asp -10	-	expression tag
Ile -9	-	expression tag
Pro -8	-	expression tag
Thr -7	-	expression tag
Thr -6	-	expression tag
Glu -5	-	expression tag
Asn -4	-	expression tag
Leu -3	-	expression tag
Tyr -2	-	expression tag
Phe -1	-	expression tag
Gln 0	-	expression tag
Gly 1	-	expression tag
Ser 2	-	expression tag
Lys 323	Glu 347	engineered mutation

O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2: 1 - 102 (UniProt: P61604)

PDB	External Database	Details
Lys 103	-	expression tag
Leu 104	-	expression tag
Ala 105	-	expression tag
Ala 106	-	expression tag
Ala 107	-	expression tag
Leu 108	-	expression tag
Glu 109	-	expression tag
His 110	-	expression tag
His 111	-	expression tag
His 112	-	expression tag
His 113	-	expression tag
His 114	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	28
	Total formula weight	1010726.0
Non-Polymers*	Number of molecules	28
	Total formula weight	6321.1
All*	Total formula weight	1017047.1

*Water molecules are not included.