4PG7

Crystal structure of S. aureus Homoserine Dehydrogenase at pH7.5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Homoserine dehydrogenase	polymer	468	51384.2	2	UniProt (N6FDB4) Pfam (PF03447) Pfam (PF00742) Pfam (PF22101) UniProt (by SIFTS) (A0A0M3KKV6) In PDB	Staphylococcus aureus M1064	HDH
2	A, B	ACETATE ION	non-polymer		59.0	11	Chemie (ACT)
3	A, B	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
4	A	LYSINE	non-polymer		147.2	1	Chemie (LYS)
5	B	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
6		water	water		18.0	321	Chemie (HOH)

Sequence modifications

A, B: 1 - 426 (UniProt: N6FDB4)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
Leu 427	-	expression tag
Glu 428	-	expression tag
Asp 429	-	expression tag
Pro 430	-	expression tag
Ala 431	-	expression tag
Ala 432	-	expression tag
Asn 433	-	expression tag
Lys 434	-	expression tag
Ala 435	-	expression tag
Arg 436	-	expression tag
Lys 437	-	expression tag
Glu 438	-	expression tag
Ala 439	-	expression tag
Glu 440	-	expression tag
Leu 441	-	expression tag
Ala 442	-	expression tag
Ala 443	-	expression tag
Ala 444	-	expression tag
Thr 445	-	expression tag
Ala 446	-	expression tag
Glu 447	-	expression tag
Gln 448	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	102768.4
Non-Polymers*	Number of molecules	18
	Total formula weight	1377.3
All*	Total formula weight	104145.7

*Water molecules are not included.