4PF3
Mineralocorticoid receptor ligand-binding domain with compuond 37a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mineralocorticoid receptor | polymer | 275 | 31664.6 | 1 | UniProt (P08235) Pfam (PF00104) | Homo sapiens (Human) | MR,Nuclear receptor subfamily 3 group C member 2 |
| 2 | B (A) | 6-[1-(2,2-difluoro-3-hydroxypropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one | non-polymer | 417.4 | 1 | Chemie (HFN) | |||
| 3 | C, D, E, F, G... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 8 | Chemie (EDO) | |||
| 4 | K (A) | water | water | 18.0 | 224 | Chemie (HOH) |
Sequence modifications
A: 712 - 984 (UniProt: P08235)
| PDB | External Database | Details |
|---|---|---|
| Gly 710 | - | expression tag |
| Ser 711 | - | expression tag |
| Ser 808 | Cys 812 | engineered mutation |
| Leu 810 | Ser 814 | engineered mutation |
| Val 976 | Ala 980 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31664.6 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 913.9 | |
| All* | Total formula weight | 32578.6 |
