4PBV

Crystal structure of chicken receptor protein tyrosine phosphatase sigma in complex with TrkC

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	NT-3 growth factor receptor	polymer	268	30399.4	2	UniProt (Q91044) Pfam (PF13855) Pfam (PF16920) Pfam (PF00047)	Gallus gallus (Chicken)	Neurotrophic tyrosine kinase receptor type 3,TrkC tyrosine kinase,Trk-C
2	C, D, E (C, D, E)	Protein-tyrosine phosphatase CRYPalpha1 isoform	polymer	299	32721.0	3	UniProt (Q90815) Pfam (PF07679) Pfam (PF13927) UniProt (by SIFTS) (F1NWE3)	Gallus gallus (Chicken)
3	F, G, H, I, J (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
4	K, L (D, E)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
5	M, N, O, P, Q (A, B, C, D, E)	water	water		18.0	118	Chemie (HOH)

Sequence modifications

A, B: 32 - 302 (UniProt: Q91044)

PDB	External Database	Details
Glu 29	-	expression tag
Thr 30	-	expression tag
Gly 31	-	expression tag
Gln 163	Asn 163	engineered mutation
Gln 232	Asn 232	engineered mutation
Gln 259	Asn 259	engineered mutation
Gln 267	Asn 267	engineered mutation
Gln 294	Asn 294	engineered mutation
Gly 303	-	expression tag
Thr 304	-	expression tag
Lys 305	-	expression tag
His 306	-	expression tag
His 307	-	expression tag
His 308	-	expression tag
His 309	-	expression tag
His 310	-	expression tag
His 311	-	expression tag

C, D, E: 29 - 316 (UniProt: Q90815)

PDB	External Database	Details
Glu 26	-	expression tag
Thr 27	-	expression tag
Gly 28	-	expression tag
Lys 317	-	expression tag
Gly 318	-	expression tag
His 319	-	expression tag
His 320	-	expression tag
His 321	-	expression tag
His 322	-	expression tag
His 323	-	expression tag
His 324	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	158961.8
Non-Polymers*	Number of molecules	7
	Total formula weight	1298.2
All*	Total formula weight	160260.0

*Water molecules are not included.