4P6W

Crystal Structure of mometasone furoate-bound glucocorticoid receptor ligand binding domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Glucocorticoid receptor	polymer	252	29284.0	1	UniProt (P04150) Pfam (PF00104) In PDB	Homo sapiens (Human)	GR,Nuclear receptor subfamily 3 group C member 1
2	B	Nuclear receptor coactivator 2	polymer	12	1406.6	1	UniProt (Q15596) In PDB	Homo sapiens	NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2
3	A	MOMETASONE FUROATE	non-polymer		521.4	1	Chemie (MOF)
4		water	water		18.0	130	Chemie (HOH)

Sequence modifications

A: 526 - 777 (UniProt: P04150)

PDB	External Database	Details
Ala 602	Phe 602	engineered mutation
Tyr 622	Cys 622	engineered mutation
Val 668	Thr 668	engineered mutation
Thr 674	Ser 674	engineered mutation
Ile 675	Val 675	engineered mutation
Ala 699	Lys 699	engineered mutation
Ala 703	Lys 703	engineered mutation

B: 741 - 752 (UniProt: Q15596)

PDB	External Database	Details
Ala 741	Glu 741	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	30690.7
Non-Polymers*	Number of molecules	1
	Total formula weight	521.4
All*	Total formula weight	31212.1

*Water molecules are not included.