4P44
X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a phosphoramidate inhibitor JRB-4-81
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Glutamate carboxypeptidase 2 | polymer | 707 | 79614.8 | 1 | UniProt (Q04609) Pfam (PF02225) Pfam (PF04389) Pfam (PF04253) In PDB | Homo sapiens (Human) | Cell growth-inhibiting gene 27 protein, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, FGCP, Glutamate carboxypeptidase II, GCPII, Membrane glutamate carboxypeptidase, mGCP, N-acetylated-alpha-linked acidic dipeptidase I, NAALADase I, Prostate-specific membrane antigen, PSMA, Pteroylpoly-gamma-glutamate carboxypeptidase |
| 2 | B, C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 3 | E | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 4 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 5 | A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 7 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | A | N-(4-fluorobenzoyl)-L-alloisoleucyl-O-[(S)-{[(1S)-1,3-dicarboxypropyl]amino}(hydroxy)phosphoryl]-L-serine | non-polymer | 549.4 | 1 | Chemie (2F7) | |||
| 9 | water | water | 18.0 | 603 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 79614.8 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2021.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1419.4 | |
| All* | Total formula weight | 83056.0 |
