4P3O
Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Threonine--tRNA ligase | polymer | 410 | 47927.5 | 2 | UniProt (P0A8M3) Pfam (PF00587) Pfam (PF03129) In PDB | Escherichia coli | Threonyl-tRNA synthetase, ThrRS |
| 2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | A, B | (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid | non-polymer | 489.6 | 2 | Chemie (2CR) | |||
| 4 | A, B | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 5 | water | water | 18.0 | 351 | Chemie (HOH) |
Sequence modifications
A, B: 242 - 642 (UniProt: P0A8M3)
| PDB | External Database | Details |
|---|---|---|
| Met 241 | - | initiating methionine |
| Leu 643 | - | expression tag |
| Glu 644 | - | expression tag |
| His 645 | - | expression tag |
| His 646 | - | expression tag |
| His 647 | - | expression tag |
| His 648 | - | expression tag |
| His 649 | - | expression tag |
| His 650 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 95855.0 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1570.6 | |
| All* | Total formula weight | 97425.6 |
