4P3N
Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Threonine--tRNA ligase, cytoplasmic | polymer | 415 | 48468.0 | 4 | UniProt (P26639) Pfam (PF00587) Pfam (PF03129) | Homo sapiens (Human) | Threonyl-tRNA synthetase, ThrRS |
| 2 | E, G, I, K (A, B, C, D) | (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid | non-polymer | 489.6 | 4 | Chemie (2CR) PubChem (310900) PubChem (5459085) PubChem (6374139) PubChem (6436801) PubChem (6477012) PubChem (12137312) PubChem (17757208) PubChem (23724539) PubChem (46926332) PubChem (99339) PubChem (5357974) PubChem (124526835) PubChem (12300208) PubChem (162968091) PubChem (162968093) PubChem (169423551) PubChem (170924086) PubChem (175666814) PubChem (70940715) PubChem (70940716) PubChem (90660447) PubChem (94248154) PubChem (94986566) PubChem (94986567) PubChem (94986568) PubChem (124930431) PubChem (124930432) PubChem (131858071) PubChem (133655849) PubChem (145967635) PubChem (145967719) PubChem (145970572) PubChem (146684015) PubChem (146684017) PubChem (162968092) PubChem (162968094) PubChem (163190275) | |||
| 3 | F, H, J, L (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 389 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 322 - 723 (UniProt: P26639)
| PDB | External Database | Details |
|---|---|---|
| Met 309 | - | expression tag |
| Gly 310 | - | expression tag |
| Ser 311 | - | expression tag |
| Ser 312 | - | expression tag |
| His 313 | - | expression tag |
| His 314 | - | expression tag |
| His 315 | - | expression tag |
| His 316 | - | expression tag |
| His 317 | - | expression tag |
| His 318 | - | expression tag |
| Ser 319 | - | expression tag |
| Ser 320 | - | expression tag |
| Gly 321 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 193871.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2220.2 | |
| All* | Total formula weight | 196092.1 |
