4P3N
Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Threonine--tRNA ligase, cytoplasmic | polymer | 415 | 48468.0 | 4 | UniProt (P26639) Pfam (PF00587) Pfam (PF03129) | Homo sapiens (Human) | Threonyl-tRNA synthetase, ThrRS |
| 2 | E, G, I, K (A, B, C, D) | (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid | non-polymer | 489.6 | 4 | Chemie (2CR) | |||
| 3 | F, H, J, L (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 389 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 322 - 723 (UniProt: P26639)
| PDB | External Database | Details |
|---|---|---|
| Met 309 | - | expression tag |
| Gly 310 | - | expression tag |
| Ser 311 | - | expression tag |
| Ser 312 | - | expression tag |
| His 313 | - | expression tag |
| His 314 | - | expression tag |
| His 315 | - | expression tag |
| His 316 | - | expression tag |
| His 317 | - | expression tag |
| His 318 | - | expression tag |
| Ser 319 | - | expression tag |
| Ser 320 | - | expression tag |
| Gly 321 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 193871.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2220.2 | |
| All* | Total formula weight | 196092.1 |
