4P39
Crystal structure of the human C5aR antagonist C5a-A8
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Complement C5 | polymer | 77 | 8365.7 | 4 | UniProt (P01031) Pfam (PF01821) | Homo sapiens (Human) | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 |
| 2 | E, F, G, H (A, B, C, D) | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 678 - 747 (UniProt: P01031)
| PDB | External Database | Details |
|---|---|---|
| Gly 671 | - | expression tag |
| Ala 672 | - | expression tag |
| Gly 673 | - | expression tag |
| Ala 674 | - | expression tag |
| Ala 675 | - | expression tag |
| Gly 676 | - | expression tag |
| Ser 677 | - | expression tag |
| Arg 704 | Cys 704 | engineered mutation |
| Phe 744 | His 744 | engineered mutation |
| Arg 746 | Asp 746 | engineered mutation |
| Ser 747 | Met 747 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 33462.7 | |
| All* | Total formula weight | 33462.7 |
