4P39

Crystal structure of the human C5aR antagonist C5a-A8

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Complement C5	polymer	77	8365.7	4	UniProt (P01031) Pfam (PF01821) In PDB	Homo sapiens (Human)	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
2		water	water		18.0	22	Chemie (HOH)

Sequence modifications

A, B, C, D: 678 - 747 (UniProt: P01031)

PDB	External Database	Details
Gly 671	-	expression tag
Ala 672	-	expression tag
Gly 673	-	expression tag
Ala 674	-	expression tag
Ala 675	-	expression tag
Gly 676	-	expression tag
Ser 677	-	expression tag
Arg 704	Cys 704	engineered mutation
Phe 744	His 744	engineered mutation
Arg 746	Asp 746	engineered mutation
Ser 747	Met 747	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	33462.7
All*	Total formula weight	33462.7

*Water molecules are not included.