4OVV
Crystal Structure of PI3Kalpha in complex with diC4-PIP2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | polymer | 1096 | 127822.6 | 1 | UniProt (P42336) Pfam (PF02192) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) | Homo sapiens | PtdIns-3-kinase subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha, p110alpha, Phosphoinositide-3-kinase catalytic alpha polypeptide, Serine/threonine protein kinase PIK3CA |
| 2 | B (B) | Phosphatidylinositol 3-kinase regulatory subunit alpha | polymer | 279 | 33667.0 | 1 | UniProt (P27986) Pfam (PF00017) Pfam (PF16454) | Homo sapiens | PtdIns-3-kinase regulatory subunit alpha, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, PtdIns-3-kinase regulatory subunit p85-alpha |
| 3 | C, E (A, B) | (2R)-3-{[(R)-HYDROXY{[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIHYDROXY-4,5-BIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1 ,2-DIYL DIBUTANOATE | non-polymer | 634.4 | 2 | Chemie (PBU) | |||
| 4 | D (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 5 | F (A) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A: 1 - 1068 (UniProt: P42336)
| PDB | External Database | Details |
|---|---|---|
| Met -28 | - | expression tag |
| Ser -27 | - | expression tag |
| Tyr -26 | - | expression tag |
| Tyr -25 | - | expression tag |
| His -24 | - | expression tag |
| His -23 | - | expression tag |
| His -22 | - | expression tag |
| His -21 | - | expression tag |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| Asp -18 | - | expression tag |
| Tyr -17 | - | expression tag |
| Asp -16 | - | expression tag |
| Ile -15 | - | expression tag |
| Pro -14 | - | expression tag |
| Thr -13 | - | expression tag |
| Thr -12 | - | expression tag |
| Glu -10 | - | expression tag |
| Asn -9 | - | expression tag |
| Leu -8 | - | expression tag |
| Tyr -7 | - | expression tag |
| Phe -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 161489.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1363.7 | |
| All* | Total formula weight | 162853.2 |
