4OU3

Crystal structure of porcine aminopeptidase N complexed with CNGRCG tumor-homing peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Aminopeptidase N	polymer	908	103521.2	1	UniProt (P15145) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838)	Sus scrofa (pig)	AP-N, pAPN, Alanyl aminopeptidase, Aminopeptidase M, AP-M, Microsomal aminopeptidase, gp130
2	B (B)	tumor-homing peptide	polymer	6	609.7	1
3	C, D, E, F, G... (C, D, E, F, G...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	8	In PDB GlyTouCan (G42666HT)
4	K (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
5	L, M (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
6	N, O, P, Q, R... (A)	SULFATE ION	non-polymer		96.1	10	Chemie (SO4)
7	X, Y (A, B)	water	water		18.0	906	Chemie (HOH)

Sequence modifications

A: 63 - 963 (UniProt: P15145)

PDB	External Database	Details
Phe 107	Leu 107	conflict
Ser 964	-	expression tag
His 965	-	expression tag
His 966	-	expression tag
His 967	-	expression tag
His 968	-	expression tag
His 969	-	expression tag
His 970	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	104130.9
Branched	Number of molecules	8
	Total formula weight	3395.2
Non-Polymers*	Number of molecules	13
	Total formula weight	1468.5
All*	Total formula weight	108994.5

*Water molecules are not included.