4OS6
Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK604 (bicyclic 2)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Urokinase-type plasminogen activator | polymer | 245 | 27586.4 | 1 | UniProt (P00749) Pfam (PF00089) In PDB | Homo sapiens (human) | U-plasminogen activator, uPA, Urokinase-type plasminogen activator long chain A, Urokinase-type plasminogen activator short chain A, Urokinase-type plasminogen activator chain B |
2 | B | bicyclic peptide UK604 (bicyclic 2) | polymer | 14 | 1478.8 | 1 | BIRD (PRD_001225) | ||
3 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
4 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
5 | water | water | 18.0 | 177 | Chemie (HOH) |
Sequence modifications
A: 16 - 242 (UniProt: P00749)
PDB | External Database | Details |
---|---|---|
Ala 122 | Cys 299 | engineered mutation |
Gln 145 | Asn 322 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 29065.2 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 251.2 | |
All* | Total formula weight | 29316.4 |