4OS4
Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK603 (bicyclic 1)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Urokinase-type plasminogen activator | polymer | 245 | 27586.4 | 1 | UniProt (P00749) Pfam (PF00089) In PDB | Homo sapiens (human) | U-plasminogen activator, uPA, Urokinase-type plasminogen activator long chain A, Urokinase-type plasminogen activator short chain A, Urokinase-type plasminogen activator chain B |
| 2 | B | bicyclic peptide UK603 (bicyclic 1) | polymer | 15 | 1549.9 | 1 | BIRD (PRD_001224) | ||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 6 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | water | water | 18.0 | 197 | Chemie (HOH) |
Sequence modifications
A: 16 - 242 (UniProt: P00749)
| PDB | External Database | Details |
|---|---|---|
| Ala 122 | Cys 299 | engineered mutation |
| Gln 145 | Asn 322 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29136.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 378.7 | |
| All* | Total formula weight | 29515.0 |
