4OQD

Crystal structure of the tylM1 N,N-dimethyltransferase in complex with SAH and TDP-Qui3NMe2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase	polymer	263	28537.9	4	UniProt (P95748) Pfam (PF13649) In PDB	Streptomyces fradiae	Tylosin biosynthesis protein M1
2	A, B, C, D	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	4	Chemie (SAH)
3	A, B, C, D	TDP-3,6-dideoxy-3-N,N-dimethylglucose	non-polymer		575.4	4	Chemie (QDM)
4		water	water		18.0	647	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 255 (UniProt: P95748)

PDB	External Database	Details
Leu 256	-	expression tag
Glu 257	-	expression tag
His 258	-	expression tag
His 259	-	expression tag
His 260	-	expression tag
His 261	-	expression tag
His 262	-	expression tag
His 263	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	114151.5
Non-Polymers*	Number of molecules	8
	Total formula weight	3839.2
All*	Total formula weight	117990.8

*Water molecules are not included.