4OQD

Crystal structure of the tylM1 N,N-dimethyltransferase in complex with SAH and TDP-Qui3NMe2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase	polymer	263	28537.9	4	UniProt (P95748)	Streptomyces fradiae	Tylosin biosynthesis protein M1
2	E, G, I, K (A, B, C, D)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	4	Chemie (SAH) PubChem (16760024) PubChem (193) PubChem (25210495) PubChem (13792) PubChem (177678424) PubChem (44361184) PubChem (21125603) PubChem (46936206) PubChem (50989525) PubChem (25203782) PubChem (51380914) PubChem (52224398) PubChem (189149) PubChem (57544532) PubChem (439155) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (52224400) PubChem (5284331) PubChem (6419189) PubChem (118374891) PubChem (118560068) PubChem (71170554) PubChem (13231890) PubChem (164157219) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525)
3	F, H, J, L (A, B, C, D)	TDP-3,6-dideoxy-3-N,N-dimethylglucose	non-polymer		575.4	4	Chemie (QDM) PubChem (46173793) PubChem (59997807) PubChem (443518) PubChem (56927734) PubChem (89290030) PubChem (89291393) PubChem (10231768)
4	M, N, O, P (A, B, C, D)	water	water		18.0	647	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 255 (UniProt: P95748)

PDB	External Database	Details
Leu 256	-	expression tag
Glu 257	-	expression tag
His 258	-	expression tag
His 259	-	expression tag
His 260	-	expression tag
His 261	-	expression tag
His 262	-	expression tag
His 263	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	114151.5
Non-Polymers*	Number of molecules	8
	Total formula weight	3839.2
All*	Total formula weight	117990.8

*Water molecules are not included.