4OMQ

Crystal structure of the intertwined dimer of the c-Src tyrosine kinase SH3 domain mutant S94A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Proto-oncogene tyrosine-protein kinase Src	polymer	77	8692.6	1	UniProt (P00523) Pfam (PF00018) In PDB	Gallus gallus (bantam chickens)	Proto-oncogene c-Src, pp60c-src, p60-Src
2	A	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
3	A	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
4	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
5		water	water		18.0	23	Chemie (HOH)

Sequence modifications

A: 85 - 140 (UniProt: P00523)

PDB	External Database	Details
Met 64	-	initiating methionine
Gly 65	-	expression tag
Ser 66	-	expression tag
Ser 67	-	expression tag
His 68	-	expression tag
His 69	-	expression tag
His 70	-	expression tag
His 71	-	expression tag
His 72	-	expression tag
His 73	-	expression tag
Ser 74	-	expression tag
Ser 75	-	expression tag
Gly 76	-	expression tag
Leu 77	-	expression tag
Val 78	-	expression tag
Pro 79	-	expression tag
Arg 80	-	expression tag
Gly 81	-	expression tag
Ser 82	-	expression tag
His 83	-	expression tag
Met 84	-	expression tag
Ala 94	Ser 94	engineered mutation
Arg 128	Gln 128	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	8692.6
Non-Polymers*	Number of molecules	4
	Total formula weight	458.5
All*	Total formula weight	9151.0

*Water molecules are not included.