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4OLB

Crystal Structure of Human Argonaute2 Bound to Tryptophan

Replaces:  4EI3
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Protein argonaute-2polymer85997378.21UniProt (Q9UKV8)
Pfam (PF16486)
Pfam (PF08699)
Pfam (PF02170)
Pfam (PF16488)
Pfam (PF16487)
Pfam (PF02171)
Homo sapiens (human)Argonaute2, hAgo2, Eukaryotic translation initiation factor 2C 2, eIF-2C 2, eIF2C 2, PAZ Piwi domain protein, PPD, Protein slicer
2B
(B)
5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*U)-3'polymer103224.11Homo sapiens (human)
3C, D
(A)
TRYPTOPHANnon-polymer204.22Chemie (TRP)
4E
(A)
waterwater18.07Chemie (HOH)
Sequence modifications
A: 1 - 859 (UniProt: Q9UKV8)
PDBExternal DatabaseDetails
Asp 387Ser 387engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight100602.2
Non-Polymers*Number of molecules2
Total formula weight408.4
All*Total formula weight101010.7
*Water molecules are not included.

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PDB entries from 2025-06-18

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