4OJ4
Crystal structure of V290M PPARgamma mutant in complex with diclofenac
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Peroxisome proliferator-activated receptor gamma | polymer | 278 | 31766.9 | 1 | UniProt (P37231) Pfam (PF00104) | Homo sapiens (human) | PPAR-gamma, Nuclear receptor subfamily 1 group C member 3 |
| 2 | B (A) | 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID | non-polymer | 296.1 | 1 | Chemie (DIF) | |||
| 3 | C, D (A) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 4 | E (A) | water | water | 18.0 | 58 | Chemie (HOH) |
Sequence modifications
A: 204 - 477 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Gly 200 | - | expression tag |
| Ser 201 | - | expression tag |
| His 202 | - | expression tag |
| Met 203 | - | expression tag |
| Met 290 | Val 318 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31766.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 376.3 | |
| All* | Total formula weight | 32143.2 |
