4OHP

Human GKRP bound to AMG-3227 and S6P

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Glucokinase regulatory protein	polymer	638	70306.6	2	UniProt (Q14397) Pfam (PF20741) In PDB	Homo sapiens (human)	Glucokinase regulator
2	A, B	4-[(2S)-4-[(6-aminopyridin-3-yl)sulfonyl]-2-(prop-1-yn-1-yl)piperazin-1-yl]-N-methylbenzenesulfonamide	non-polymer		449.5	2	Chemie (2TJ)
3	A, B	D-SORBITOL-6-PHOSPHATE	non-polymer		262.2	2	Chemie (S6P)
4	B, A	IODIDE ION	non-polymer		126.9	24	Chemie (IOD)
5	B	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6	B	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
7		water	water		18.0	158	Chemie (HOH)

Sequence modifications

A, B: 1 - 625 (UniProt: Q14397)

PDB	External Database	Details
Met -11	-	expression tag
Ala -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Asp -3	-	expression tag
Glu -2	-	expression tag
Val -1	-	expression tag
Asp 0	-	expression tag
Gly 626	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	140613.2
Non-Polymers*	Number of molecules	32
	Total formula weight	4849.4
All*	Total formula weight	145462.6

*Water molecules are not included.