4OHM

Human GKRP bound to AMG-0771 and sorbitol-6-phosphate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Glucokinase regulatory protein	polymer	638	70306.6	2	UniProt (Q14397) Pfam (PF22645) Pfam (PF22198) Pfam (PF20741)	Homo sapiens (human)	Glucokinase regulator
2	C, P (A, B)	(2S)-2-{4-[(2S)-4-[(6-aminopyridin-3-yl)sulfonyl]-2-(prop-1-yn-1-yl)piperazin-1-yl]phenyl}-3,3,3-trifluoropropane-1,2-diol	non-polymer		484.5	2	Chemie (2TF) PubChem (89761004) PubChem (89761279) PubChem (89762362) PubChem (89762364) PubChem (71664750) PubChem (76871909) PubChem (89761060)
3	D, Q (A, B)	D-SORBITOL-6-PHOSPHATE	non-polymer		262.2	2	Chemie (S6P) PubChem (618) PubChem (21968234) PubChem (130418) PubChem (152306) PubChem (17754155) PubChem (440969) PubChem (445703) PubChem (53827506) PubChem (92177220) PubChem (14620017) PubChem (92209470) PubChem (124335010) PubChem (163321747) PubChem (165361689)
4	AA, BA, CA, DA, E... (B, A)	IODIDE ION	non-polymer		126.9	24	Chemie (IOD) PubChem (30165)
5	EA (B)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL) PubChem (753)
6	FA, GA, HA (B)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
7	IA, JA (A, B)	water	water		18.0	193	Chemie (HOH)

Sequence modifications

A, B: 1 - 625 (UniProt: Q14397)

PDB	External Database	Details
Met -11	-	expression tag
Ala -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Asp -3	-	expression tag
Glu -2	-	expression tag
Val -1	-	expression tag
Asp 0	-	expression tag
Gly 626	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	140613.2
Non-Polymers*	Number of molecules	32
	Total formula weight	4919.3
All*	Total formula weight	145532.5

*Water molecules are not included.