4OHL

LEOPARD Syndrome-Associated SHP2/T468M mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Tyrosine-protein phosphatase non-receptor type 11	polymer	536	61791.7	2	UniProt (Q06124) Pfam (PF00017) Pfam (PF00102) In PDB	Homo sapiens (human)	Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SHP-2, Shp2, SH-PTP3
2		water	water		18.0	330	Chemie (HOH)

Sequence modifications

A, B: 1 - 528 (UniProt: Q06124)

PDB	External Database	Details
-	Gln 408	deletion
-	Ala 409	deletion
-	Leu 410	deletion
-	Leu 411	deletion
Met 468	Thr 472	engineered mutation
Leu 529	-	expression tag
Glu 530	-	expression tag
His 531	-	expression tag
His 532	-	expression tag
His 533	-	expression tag
His 534	-	expression tag
His 535	-	expression tag
His 536	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	123583.5
All*	Total formula weight	123583.5

*Water molecules are not included.