4OHE
LEOPARD Syndrome-Associated SHP2/G464A mutant
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein phosphatase non-receptor type 11 | polymer | 536 | 61775.7 | 1 | UniProt (Q06124) Pfam (PF00017) Pfam (PF00102) In PDB | Homo sapiens (human) | Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SHP-2, Shp2, SH-PTP3 |
2 | water | water | 18.0 | 131 | Chemie (HOH) |
Sequence modifications
A: 1 - 528 (UniProt: Q06124)
PDB | External Database | Details |
---|---|---|
- | Gln 408 | deletion |
- | Ala 409 | deletion |
- | Leu 410 | deletion |
- | Leu 411 | deletion |
Ala 464 | Gly 468 | engineered mutation |
Leu 529 | - | expression tag |
Glu 530 | - | expression tag |
His 531 | - | expression tag |
His 532 | - | expression tag |
His 533 | - | expression tag |
His 534 | - | expression tag |
His 535 | - | expression tag |
His 536 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 61775.7 | |
All* | Total formula weight | 61775.7 |