4OEM
Crystal structure of Cathepsin C in complex with dipeptide substrates
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dipeptidyl peptidase 1 Heavy chain | polymer | 370 | 42037.4 | 1 | UniProt (P53634) Pfam (PF08773) Pfam (PF00112) | Homo sapiens (human) | Cathepsin C, Cathepsin J, Dipeptidyl peptidase I, DPP-I, DPPI, Dipeptidyl transferase |
| 2 | B (B) | Dipeptidyl peptidase 1 Light chain | polymer | 70 | 7712.6 | 1 | UniProt (P53634) | Homo sapiens (human) | Cathepsin C, Cathepsin J, Dipeptidyl peptidase I, DPP-I, DPPI, Dipeptidyl transferase |
| 3 | C (A) | GLYCINE | non-polymer | 75.1 | 1 | Chemie (GLY) | |||
| 4 | D (A) | LYSINE | non-polymer | 147.2 | 1 | Chemie (LYS) | |||
| 5 | E (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 6 | F, G, H (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 7 | I (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | J, K, L, M (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 9 | N, O (A, B) | water | water | 18.0 | 324 | Chemie (HOH) |
Sequence modifications
A: 1 - 370 (UniProt: P53634)
B: 371 - 439 (UniProt: P53634)
| PDB | External Database | Details |
|---|---|---|
| Thr 129 | Ile 153 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Glu 440 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49749.9 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1265.7 | |
| All* | Total formula weight | 51015.6 |
