4OED

Crystal structure of AR-LBD bound with co-regulator peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Androgen receptor	polymer	250	29088.1	1	UniProt (P10275) Pfam (PF00104)	Homo sapiens (human)	Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4
2	B (B)	Protein BUD31 homolog	polymer	15	2017.4	1	UniProt (P41223)	Homo sapiens	Protein EDG-2, Protein G10 homolog
3	C (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4	D (A)	5-ALPHA-DIHYDROTESTOSTERONE	non-polymer		290.4	1	Chemie (DHT) PubChem (16395945) PubChem (1779160) PubChem (15) PubChem (23729584) PubChem (10635) PubChem (44264584) PubChem (44307156) PubChem (44308180) PubChem (44314545) PubChem (147320) PubChem (1779165) PubChem (54132599) PubChem (1779163) PubChem (44403751) PubChem (67080676) PubChem (68213431) PubChem (70627790) PubChem (57253355) PubChem (667503) PubChem (76333143) PubChem (2748143) PubChem (928651) PubChem (11302) PubChem (90350225) PubChem (968803) PubChem (6951009) PubChem (124916763) PubChem (6432518) PubChem (133612463) PubChem (7052570) PubChem (7052571) PubChem (11869360) PubChem (9965809) PubChem (10379482) PubChem (10902374) PubChem (124305346) PubChem (124335861) PubChem (124350819) PubChem (124362930) PubChem (124402106) PubChem (124420348) PubChem (11860392) PubChem (11867857) PubChem (11867858) PubChem (11867859) PubChem (11867860) PubChem (11869358) PubChem (11869359) PubChem (11869361) PubChem (11914201) PubChem (11920866) PubChem (12446746) PubChem (12446747) PubChem (12446748) PubChem (12446749) PubChem (12446752) PubChem (124907326) PubChem (124907327) PubChem (16111632) PubChem (134753818) PubChem (139564330) PubChem (141909893) PubChem (142776876) PubChem (145087815) PubChem (156740897) PubChem (162854571) PubChem (162854572) PubChem (162854573) PubChem (164663566) PubChem (165146196) PubChem (165431280)
5	E (A)	water	water		18.0	31	Chemie (HOH)

Sequence modifications

A: 670 - 919 (UniProt: P10275)

PDB	External Database	Details
Ala 760	Arg 760	engineered mutation

B: -2 - 12 (UniProt: P41223)

PDB	External Database	Details
Tyr 12	Ile 70	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	31105.5
Non-Polymers*	Number of molecules	2
	Total formula weight	386.5
All*	Total formula weight	31492.0

*Water molecules are not included.