4O9R

Human Smoothened Receptor structure in complex with cyclopamine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Smoothened homolog/Soluble cytochrome b562 chimeric protein	polymer	468	52395.2	1	UniProt (Q99835) UniProt (P0ABE7) Pfam (PF01534) Pfam (PF07361) In PDB	Homo sapiens
2	A	Cyclopamine	non-polymer		411.6	1	Chemie (CY8)

Sequence modifications

A: 190 - 433 (UniProt: Q99835)

PDB	External Database	Details
Gly 187	-	expression tag
Gly 188	-	expression tag
Thr 189	-	expression tag

A: 1001 - 1106 (UniProt: P0ABE7)

PDB	External Database	Details
Trp 1007	Met 29	engineered mutation
Ile 1102	His 124	engineered mutation
Leu 1106	Arg 128	engineered mutation

A: 441 - 555 (UniProt: Q99835)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	52395.2
Non-Polymers*	Number of molecules	1
	Total formula weight	411.6
All*	Total formula weight	52806.8

*Water molecules are not included.