4O91
Crystal Structure of type II inhibitor NG25 bound to TAK1-TAB1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimera | polymer | 314 | 35463.9 | 1 | UniProt (O43318) UniProt (Q15750) Pfam (PF07714) | Homo sapiens (human) | |
| 2 | B (A) | N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide | non-polymer | 537.6 | 1 | Chemie (NG2) | |||
| 3 | C (A) | water | water | 18.0 | 111 | Chemie (HOH) |
Sequence modifications
A: 31 - 303 (UniProt: O43318)
A: 468 - 504 (UniProt: Q15750)
| PDB | External Database | Details |
|---|---|---|
| Ser 27 | - | expression tag |
| Leu 28 | - | expression tag |
| His 29 | - | expression tag |
| Met 30 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35463.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 537.6 | |
| All* | Total formula weight | 36001.4 |
