4O8Z
Crystal structure of human SIRT3 in complex with compound (2-butylbenzofuran-3-yl)(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)methanone
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | polymer | 303 | 33913.8 | 1 | UniProt (Q9NTG7) Pfam (PF02146) In PDB | Homo sapiens (human) | hSIRT3, Regulatory protein SIR2 homolog 3, SIR2-like protein 3 |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone | non-polymer | 645.3 | 1 | Chemie (BBI) | |||
4 | water | water | 18.0 | 217 | Chemie (HOH) |
Sequence modifications
A: 116 - 399 (UniProt: Q9NTG7)
PDB | External Database | Details |
---|---|---|
His 97 | - | expression tag |
His 98 | - | expression tag |
His 99 | - | expression tag |
His 100 | - | expression tag |
His 101 | - | expression tag |
His 102 | - | expression tag |
Asp 103 | - | expression tag |
Tyr 104 | - | expression tag |
Asp 105 | - | expression tag |
Ile 106 | - | expression tag |
Pro 107 | - | expression tag |
Thr 108 | - | expression tag |
Thr 109 | - | expression tag |
Glu 110 | - | expression tag |
Asn 111 | - | expression tag |
Leu 112 | - | expression tag |
Tyr 113 | - | expression tag |
Phe 114 | - | expression tag |
Gln 115 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 33913.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 710.7 | |
All* | Total formula weight | 34624.5 |