4O3T

Zymogen HGF-beta/MET with Zymogen Activator Peptide ZAP.14

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Hepatocyte growth factor	polymer	240	26800.9	1	UniProt (P14210) Pfam (PF00089)	Homo sapiens (human)	Hepatopoietin-A, Scatter factor, SF, Hepatocyte growth factor alpha chain, Hepatocyte growth factor beta chain
2	B (B)	Hepatocyte growth factor receptor	polymer	551	62714.1	1	UniProt (P08581) Pfam (PF01403) Pfam (PF01437)	Homo sapiens (human)	HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met
3	C (P)	ZAP.14	polymer	11	1322.5	1		synthetic
4	D (C)	alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	1	In PDB GlyTouCan (G11971MR)
5	E (A)	PENTAETHYLENE GLYCOL	non-polymer		238.3	1	Chemie (1PE)

Sequence modifications

A: 495 - 728 (UniProt: P14210)

PDB	External Database	Details
Gly 495	Val 495	engineered mutation
Ser 604	Cys 604	engineered mutation
His 729	-	expression tag
His 730	-	expression tag
His 731	-	expression tag
His 732	-	expression tag
His 733	-	expression tag
His 734	-	expression tag

B: 25 - 567 (UniProt: P08581)

PDB	External Database	Details
His 568	-	expression tag
His 569	-	expression tag
His 570	-	expression tag
His 571	-	expression tag
His 572	-	expression tag
His 573	-	expression tag
His 574	-	expression tag
His 575	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	90837.6
Branched	Number of molecules	1
	Total formula weight	570.5
Non-Polymers*	Number of molecules	1
	Total formula weight	238.3
All*	Total formula weight	91646.4

*Water molecules are not included.