4O28

Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Nicotinamide phosphoribosyltransferase	polymer	501	57002.5	2	UniProt (P43490) Pfam (PF18127) Pfam (PF04095) In PDB	Homo sapiens (human)	NAmPRTase, Nampt, Pre-B-cell colony-enhancing factor 1, Pre-B cell-enhancing factor, Visfatin
2	A, B	N-{4-[(3,5-difluorophenyl)sulfonyl]benzyl}imidazo[1,2-a]pyridine-6-carboxamide	non-polymer		427.4	2	Chemie (1QS)
3	A, B	PHOSPHATE ION	non-polymer		95.0	4	Chemie (PO4)
4	A, B	1,2-ETHANEDIOL	non-polymer		62.1	13	Chemie (EDO)
5		water	water		18.0	794	Chemie (HOH)

Sequence modifications

A, B: 1 - 491 (UniProt: P43490)

PDB	External Database	Details
Phe 165	Ser 165	engineered mutation
Leu 492	-	expression tag
Glu 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag
His 496	-	expression tag
His 497	-	expression tag
His 498	-	expression tag
His 499	-	expression tag
His 500	-	expression tag
His 501	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	114005.0
Non-Polymers*	Number of molecules	19
	Total formula weight	2041.6
All*	Total formula weight	116046.6

*Water molecules are not included.