4O19

The crystal structure of a mutant NAMPT (G217V)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Nicotinamide phosphoribosyltransferase	polymer	501	56984.5	2	UniProt (P43490) Pfam (PF18127) Pfam (PF04095)	Homo sapiens (human)	NAmPRTase, Nampt, Pre-B-cell colony-enhancing factor 1, Pre-B cell-enhancing factor, Visfatin
2	C, G (A, B)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
3	D, E, F, H, I... (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	11	Chemie (EDO)
4	P, Q (A, B)	water	water		18.0	1024	Chemie (HOH)

Sequence modifications

A, B: 1 - 491 (UniProt: P43490)

PDB	External Database	Details
Val 217	Gly 217	engineered mutation
Leu 492	-	expression tag
Glu 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag
His 496	-	expression tag
His 497	-	expression tag
His 498	-	expression tag
His 499	-	expression tag
His 500	-	expression tag
His 501	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	113968.9
Non-Polymers*	Number of molecules	13
	Total formula weight	872.7
All*	Total formula weight	114841.6

*Water molecules are not included.