4O18

Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Nicotinamide phosphoribosyltransferase	polymer	501	56956.4	2	UniProt (P43490) Pfam (PF18127) Pfam (PF04095) In PDB	Homo sapiens (human)	NAmPRTase, Nampt, Pre-B-cell colony-enhancing factor 1, Pre-B cell-enhancing factor, Visfatin
2	A, B	PHOSPHATE ION	non-polymer		95.0	4	Chemie (PO4)
3	A, B	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
4		water	water		18.0	737	Chemie (HOH)

Sequence modifications

A, B: 1 - 491 (UniProt: P43490)

PDB	External Database	Details
Ala 217	Gly 217	engineered mutation
Leu 492	-	expression tag
Glu 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag
His 496	-	expression tag
His 497	-	expression tag
His 498	-	expression tag
His 499	-	expression tag
His 500	-	expression tag
His 501	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	113912.8
Non-Polymers*	Number of molecules	6
	Total formula weight	504.0
All*	Total formula weight	114416.8

*Water molecules are not included.