4O16
Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Nicotinamide phosphoribosyltransferase | polymer | 501 | 57002.5 | 1 | UniProt (P43490) Pfam (PF18127) Pfam (PF04095) | Homo sapiens (human) | NAmPRTase, Nampt, Pre-B-cell colony-enhancing factor 1, Pre-B cell-enhancing factor, Visfatin |
| 2 | B (A) | 6-({4-[(3,5-difluorophenyl)sulfonyl]benzyl}carbamoyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)imidazo[1,2-a]pyridin-1-ium | non-polymer | 640.5 | 1 | Chemie (1XC) | |||
| 3 | C, J (A) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 4 | D, E, F, G, H... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 13 | Chemie (EDO) | |||
| 5 | R (A) | water | water | 18.0 | 250 | Chemie (HOH) |
Sequence modifications
A: 1 - 491 (UniProt: P43490)
| PDB | External Database | Details |
|---|---|---|
| Phe 165 | Ser 165 | engineered mutation |
| Leu 492 | - | expression tag |
| Glu 493 | - | expression tag |
| His 494 | - | expression tag |
| His 495 | - | expression tag |
| His 496 | - | expression tag |
| His 497 | - | expression tag |
| His 498 | - | expression tag |
| His 499 | - | expression tag |
| His 500 | - | expression tag |
| His 501 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 57002.5 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1637.4 | |
| All* | Total formula weight | 58639.8 |
