4O0E

Crystal structure of the human L-asparaginase protein T186V mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Isoaspartyl peptidase/L-asparaginase	polymer	309	32230.7	2	UniProt (Q7L266) Pfam (PF01112)	Homo sapiens (human)	Asparaginase-like protein 1, Beta-aspartyl-peptidase, Isoaspartyl dipeptidase, L-asparagine amidohydrolase, Isoaspartyl peptidase/L-asparaginase alpha chain, Isoaspartyl peptidase/L-asparaginase beta chain
2	C, D (A, B)	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
3	E, F (A, B)	water	water		18.0	177	Chemie (HOH)

Sequence modifications

A, B: 1 - 308 (UniProt: Q7L266)

PDB	External Database	Details
His 0	-	expression tag
Val 186	Thr 186	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	64461.3
Non-Polymers*	Number of molecules	2
	Total formula weight	46.0
All*	Total formula weight	64507.3

*Water molecules are not included.