4NW3

Crystal structure of MLL CXXC domain in complex with a CpG DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Histone-lysine N-methyltransferase 2A	polymer	76	8805.3	1	UniProt (Q03164) Pfam (PF02008)	Homo sapiens (human)	Lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7, Myeloid/lymphoid or mixed-lineage leukemia, Myeloid/lymphoid or mixed-lineage leukemia protein 1, Trithorax-like protein, Zinc finger protein HRX
2	B, C (B, C)	5'-D(*GP*CP*CP*AP*TP*CP*GP*AP*TP*GP*GP*C)-3'	polymer	12	3663.4	2
3	D, E (A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

A: 1147 - 1204 (UniProt: Q03164)

PDB	External Database	Details
Met 1129	-	expression tag
His 1130	-	expression tag
His 1131	-	expression tag
His 1132	-	expression tag
His 1133	-	expression tag
His 1134	-	expression tag
His 1135	-	expression tag
Ser 1136	-	expression tag
Ser 1137	-	expression tag
Gly 1138	-	expression tag
Arg 1139	-	expression tag
Glu 1140	-	expression tag
Asn 1141	-	expression tag
Leu 1142	-	expression tag
Tyr 1143	-	expression tag
Phe 1144	-	expression tag
Gln 1145	-	expression tag
Gly 1146	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	16132.1
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	16262.9

*Water molecules are not included.