4NST
Crystal structure of human Cdk12/Cyclin K in complex with ADP-aluminum fluoride
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Cyclin-dependent kinase 12 | polymer | 351 | 40765.0 | 2 | UniProt (Q9NYV4) Pfam (PF00069) | Homo sapiens (human) | Cdc2-related kinase, arginine/serine-rich, CrkRS, Cell division cycle 2-related protein kinase 7, CDC2-related protein kinase 7, Cell division protein kinase 12, hCDK12 |
| 2 | B, D (B, D) | Cyclin-K | polymer | 268 | 31429.2 | 2 | UniProt (O75909) Pfam (PF00134) Pfam (PF21797) | Homo sapiens (human) | |
| 3 | E, L (A, C) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 4 | F, M (A, C) | ALUMINUM FLUORIDE | non-polymer | 84.0 | 2 | Chemie (AF3) | |||
| 5 | G, H, I, N, O... (A, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 7 | Chemie (MG) | |||
| 6 | J, K, P, S (A, B, C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 7 | T, U, V, W (A, B, C, D) | water | water | 18.0 | 393 | Chemie (HOH) |
Sequence modifications
A, C: 714 - 1063 (UniProt: Q9NYV4)
B, D: 1 - 267 (UniProt: O75909)
| PDB | External Database | Details |
|---|---|---|
| Gly 713 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 144388.3 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1440.8 | |
| All* | Total formula weight | 145829.1 |
