4NR4
Crystal structure of the bromodomain of human CREBBP in complex with an isoxazolyl-benzimidazole ligand
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | CREB-binding protein | polymer | 119 | 14223.3 | 2 | UniProt (Q92793) Pfam (PF00439) In PDB | Homo sapiens (human) | |
| 2 | A, B | 1-(4-chlorobenzyl)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1H-benzimidazole | non-polymer | 337.8 | 3 | Chemie (2LK) | |||
| 3 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 4 | B | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | water | water | 18.0 | 286 | Chemie (HOH) |
Sequence modifications
A, B: 1081 - 1197 (UniProt: Q92793)
| PDB | External Database | Details |
|---|---|---|
| Ser 1079 | - | expression tag |
| Met 1080 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28446.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1161.9 | |
| All* | Total formula weight | 29608.5 |
