4NQS
Knob-into-hole IgG Fc
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, G | Ig gamma-1 chain C region | polymer | 213 | 24000.1 | 2 | UniProt (P01857) Pfam (PF07654) In PDB | Homo sapiens (human) | hole Fc T366S/L368A/Y407V |
2 | B, H | Ig gamma-1 chain C region | polymer | 213 | 24205.4 | 2 | UniProt (P01857) Pfam (PF07654) In PDB | Homo sapiens (human) | knob Fc T366W |
3 | D, E, I, J | miniZ | polymer | 34 | 4190.7 | 4 | Staphylococcus | ||
4 | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence modifications
A, G: 235 - 447 (UniProt: P01857)
B, H: 235 - 447 (UniProt: P01857)
PDB | External Database | Details |
---|---|---|
Glu 356 | Asp 239 | SEE REMARK 999 |
Met 358 | Leu 241 | SEE REMARK 999 |
Ser 366 | Thr 249 | engineered mutation |
Ala 368 | Leu 251 | engineered mutation |
Val 407 | Tyr 290 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Glu 356 | Asp 239 | SEE REMARK 999 |
Met 358 | Leu 241 | SEE REMARK 999 |
Trp 366 | Thr 249 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 113173.8 | |
All* | Total formula weight | 113173.8 |