4NJU
Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with tipranavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Protease | polymer | 99 | 10863.7 | 4 | UniProt (Q9J006) Pfam (PF00077) | Human immunodeficiency virus 1 | |
| 2 | E, F (A, C) | N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE | non-polymer | 602.7 | 2 | Chemie (TPV) | |||
| 3 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 375 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 99 (UniProt: Q9J006)
| PDB | External Database | Details |
|---|---|---|
| Cys 95 | Phe 95 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 43455.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1205.3 | |
| All* | Total formula weight | 44660.3 |
