4NJS
Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with non-peptidic inhibitor, GRL008
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Protease | polymer | 99 | 10863.7 | 4 | UniProt (Q9J006) Pfam (PF00077) | Human immunodeficiency virus 1 | |
| 2 | E, F (B, D) | (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[(4-carbamoylphenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate | non-polymer | 575.7 | 2 | Chemie (G08) | |||
| 3 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 378 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 99 (UniProt: Q9J006)
| PDB | External Database | Details |
|---|---|---|
| Cys 95 | Phe 95 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 43455.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1151.3 | |
| All* | Total formula weight | 44606.3 |
