4NJ3
Modulating the interaction between CDK2 and Cyclin A with a Quinoline-based inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclin-dependent kinase 2 | polymer | 299 | 34034.5 | 1 | UniProt (P24941) Pfam (PF00069) | Homo sapiens (human) | Cell division protein kinase 2, p33 protein kinase |
| 2 | B (A) | 6-(3-chlorophenyl)-2-{[(2S)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]carbamoyl}quinoline-4-carboxylic acid | non-polymer | 504.9 | 1 | Chemie (2KD) | |||
| 3 | C (A) | water | water | 18.0 | 161 | Chemie (HOH) |
Sequence modifications
A: 1 - 298 (UniProt: P24941)
| PDB | External Database | Details |
|---|---|---|
| Ace 0 | - | acetylation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34034.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 504.9 | |
| All* | Total formula weight | 34539.4 |
