4NHY

Crystal structure of human OGFOD1, 2-oxoglutarate and iron-dependent oxygenase domain containing 1, in complex with pyridine-2,4-dicarboxylic acid (2,4-PDCA)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1	polymer	562	65499.4	4	UniProt (Q8N543) Pfam (PF13661) Pfam (PF10637) In PDB	Homo sapiens (human)	Termination and polyadenylation 1 homolog
2	A, B, C, D	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN)
3	A, B, D	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
4	A, B, C, D	PYRIDINE-2,4-DICARBOXYLIC ACID	non-polymer		167.1	4	Chemie (PD2)
5		water	water		18.0	83	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 542 (UniProt: Q8N543)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	261997.7
Non-Polymers*	Number of molecules	11
	Total formula weight	1164.5
All*	Total formula weight	263162.2

*Water molecules are not included.