4NH7
Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Heat shock protein HSP 90-alpha | polymer | 233 | 26183.4 | 2 | UniProt (P07900) Pfam (PF13589) | Homo sapiens (Human) | Heat shock 86 kDa,HSP86,Lipopolysaccharide-associated protein 2,LPS-associated protein 2,Renal carcinoma antigen NY-REN-38 |
| 2 | C, G (A, B) | 4-[6,6-dimethyl-4-oxidanylidene-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]-2-[(4-oxidanylcyclohexyl)amino]benzamide | non-polymer | 464.5 | 2 | Chemie (E0G) | |||
| 3 | D, E, F, H, I (A, B) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 4 | J, K (A, B) | water | water | 18.0 | 264 | Chemie (HOH) |
Sequence modifications
A, B: 9 - 236 (UniProt: P07900)
| PDB | External Database | Details |
|---|---|---|
| Gly 4 | - | expression tag |
| Ser 5 | - | expression tag |
| Leu 6 | - | expression tag |
| His 7 | - | expression tag |
| Met 8 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 52366.8 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1389.4 | |
| All* | Total formula weight | 53756.2 |
